Glioblastoma multiforme as initial internal malignancy in Muir-Torre syndrome (MTS)
نویسندگان
چکیده
CNS: central nervous system IHC: immunohistochemistry MMR: mismatch repair MTS: Muir-Torre syndrome M uir-Torre syndrome (MTS) is an autosomal-dominant variant of Lynch hereditary cancer syndrome. MTS is defined by sebaceous neoplasms occurring in association with 1 or more internal malignancies. The sebaceous neoplasms that characterize MTS are rare among the general population and include sebaceous adenoma, sebaceoma, sebaceous carcinoma, keratoacanthoma with sebaceous differentiation, and basal cell carcinoma with sebaceous differentiation. A recent case series described several central nervous system (CNS) malignancies associated with MTS occurring after the development of colon cancer. We report a case of MTS with glioblastoma multiforme as the initial internal malignancy.
منابع مشابه
Identifying Muir-Torre syndrome in a patient with glioblastoma multiforme.
Patients with Muir-Torre syndrome, an autosomal-dominant familial tumor condition caused by germline mutation of the DNA mismatch repair genes, MSH2 or MLH1, present with tumors of the sebaceous gland and visceral malignancies characterized by microsatellite instability. Here we show development of glioblastoma multiforme in a patient with Muir-Torre syndrome. Immunohistochemical analysis of th...
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Muir-Torre syndrome (MTS) is a rare disorder characterized by the presence of at least one sebaceous gland neoplasm and at least one visceral malignancy. Sebaceous adenomas, sebaceous carcinomas, and sebaceomas (sebaceous epitheliomas) are all characteristic glandular tumors of MTS. The most common visceral malignancies associated with MTS are colorectal, followed by genitourinary. These viscer...
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